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KMID : 1101820130010010008
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Journal of Breast Disease
2013 Volume.1 No. 1 p.8 ~ p.14
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The Relationship Between Estrogen/Progesterone Receptor and Expression of mTOR/pAkt Proteins and the Analysis of Prognosis in Breast Cancer
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Han Sun-Wook
Lee Moon-Soo
Kim Sung-Yong
Kang Gil-Ho
Kim Zi-Sun
Lim Chul-Wan
Lee Ji-Hyun
Lee Hyun-Ju
Oh Mee-Hye
Lee Min-Hyuk
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Abstract
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Purpose: The phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (mTOR) pathway is a critical signaling pathway downstream of the growth factor receptor tyrosine kinase that regulates cell growth and survival. Rapamycin, an inhibitor of the mTOR, possesses antitumor activity against many tumors including breast cancer, especially against estrogen receptor (ER) positive breast cancer cell lines. In this study, the expression of mTOR and pAkt in breast cancer, its association with ER/progesterone receptor (PR) and prognosis were examined.
Methods: Formalin fixed paraffin-embedded 170 cases of the breast cancer were immunohistochemically stained, using rabbit monoclonal antibody mTOR and rabbit monoclonal antibody pAkt. Based on this, the expression pattern of ER/PR and mTOR/pAkt were analyzed, and outcomes were also investigated.
Results: mTOR expression was positive in 110 of 170 cases (64.7%) and pAkt expression was positive in 130 of 170 cases (76.5%). In correlation between clinicopathologic factors and mTOR/pAkt expression, mTOR expression was correlated with ER/PR positive and pAkt expression was correlated with age (>65), postmenopause. But there is no statistically significant in correlation between survival and mTOR/pAkt expression.
Conclusion: The expression of pAkt was correlated with postmenopausal women and increased age, and we found the expression of ER/PR increased mTOR. The results provide a rationale basis for future clinical development of mTOR inhibitor combined ER inhibitor in breast cancer.
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KEYWORD
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Breast neoplasms, Estrogen receptors, Progesterone receptors, Proto-oncogene proteins c-akt, TOR serine-threonine kinase
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